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SODIUM HYDNOCARPATE
FORMERLY KNOWN AS
SODIUM GYNOCARDATE "A"
With the compliments of
SMITH, STANISTREET & Co., Ltd., CALCUTTA.
GENERAL NOTES.
CHAUL MOOGRA OIL has for long been the best known remedy for Leprosy, but its value * greatly limited by the gastric disturbances it produces preventing patients taking it in fuil loses for sufficiently long to obtain more than temporary benefit from its use. Prolonged intramuscular injections of the Oil have been shown by Dr. Heiser to give better results than oral use, but they are very painful, and slow in their effects. Gynocardic Acid is comprised of the lower melting point fatty acids of Chaalmoogra Oil, which have been found by Sir Leopard Rogers, IM.S., to be much better tolerated orally and more eflective than the Oil itself. Moreover he has shown that the Soduim Salt of this Acid is very soluble and can be injected both subcutaneously and intravenously in Leprosy with great advantage, the intra- venous use being almost painless and more rapidly effective than any other method, (See "Lancet," February 16th, 1916 and the "British Medical Journal" October 21st, 1916) The Sodium Salts of the lower melting point Acids (about 37°C) of true Chaulmoogra Oil, derived from the seeds of the Taraktogenous kurzii, have been manufacturred and issued by Messrs. Smith, Stanistreet & Co., Ltd., of Calcutta under the name of "Sodium Gynocar- date" for some months. Further investigation have shown that preparations of some of the higher melting point Acids are so sufficiently soluble for subcutaneous and intravenous use, and produce more rapid improvement than those used earlier; while they contain a onsiderable proportion of Chaulmoogic and Hydnocarpic Acids as well as some of the lower melting point acids described by Moss as Gynocardic Acid. For the present (pending the results of further research) a mixture of the higher and lower melting point preparations being made under the more correct name of Sodium Hydnocarpate. The results so far obtainted, mainly by the intravenous use of these substances, have been recorded in the "Indian Journal of Medical Research of October 1917, but it may be stated that out of twelve cases of Leprosy, mostly of an advanced nature, who have continued the treatment for between one and two years, eight have lost all definite signs of the disease; although it is far too early to say if the results will be permanent or not, and no claim is made that the disease can be absolutely cured.
All batches made by Messrs. Smith, Stanistreet & Co, Ltd., are tested at the Calcutta School of Tropical Medicine. The Medical Staff of the Calcutta School of Tropical Medicine would be glad to receive reports of cases treated with these preparations from medical
men.
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